The Human Endocannabinoid System

Every species within the animal kingdom, contains the Endocannabinoid System (ECS), except for insects.

The ECS was named after cannabinoids, which are found abundantly in cannabis as well produced naturally within the human body.

Research conducted on cannabinoids such as THC, CBD, CBG and CBC that are produced by cannabis lead to the discovery of the Endocannabinoid System (ECS).

The ECS is taught in only 13% of medical schools. Survey of the Endocannabinoid System in Medical Schools

Think of receptors as locks and cannabinoids as the keys: when the right key ‘cannabinoid’ finds the matching lock ‘receptor,’ it opens the door and delivers a message.

Cannabinoids either bind or block specific receptors in our bodies, thus altering messages being sent through the central and peripheral nervous system.

The best way of  releasing cannabinoids in cannabis is to do so by heating the matter in order to make the trichomes, which contain the terpenes and cannabinoids, undergo a chemical change.

CB1 Receptors

CB1 Receptors control neurons present in the central and peripheral nervous system, which include the brain and spinal cord, as well as some peripheral organs and tissues.

CB1 Receptors are not present in the medulla oblongata, which is the part of the brain stem responsible for respiratory and cardiovascular functions.

*There is no risk of an overdose with cannabis, as there is no chance of causing respiratory or cardiovascular failures.

CB2 Receptors

CB2 Receptors are present in the peripheral nervous system, which are the nerves and ganglia existing outside of the brain and spinal cord. CB2 Receptors are also found profusely concentrated in the immune system, which is highly concentrated within the spleen and liver, as well as related to the reproduction of white blood cells.

Cannabis acts as a strong anti-inflammatory mediator among CB2 Receptors, assisting with cell migration and bone cell generation.

For more information on the ECS read – The Discovery of the Endocannabinoid System by Martin A. Lee

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